The Best Stem Cells Unlocking the Future of Regenerative Therapy

Wharton's Jelly Stem Cells (WJ-MSC) are stem cells with very high regenerative capabilities among various types of stem cells.
We use Wharton's Jelly Stem Cells in our treatment.

Wharton's Jelly is a gel-like tissue found within the fetal umbilical cord (umbilical cord), and is a mesenchymal tissue that forms during fetal development.
This tissue contains stem cells that can differentiate into various types of cells, and the number of stem cells that can be extracted from a single umbilical cord is very large.

Wharton's Jelly Stem Cells are umbilical cord-derived stem cells extracted from the umbilical cord's gelatinous tissue. They are referred to as "0-year-old stem cells" because they originate from newborns, making them exceptionally young and full of vitality.

Due to their inherent immaturity, Wharton's Jelly Stem Cells possess superior self-renewal and differentiation capabilities, and have been scientifically proven to excel in tissue regeneration and immunomodulation.

Given the direct impact of cell quality on therapeutic efficacy in stem cell therapy, we utilize Wharton's Jelly Stem Cells with the highest potency to deliver superior therapeutic efficacy.

From Acquisition to Culture of Wharton's Jelly Stem Cells

Wharton's Jelly Stem Cells are extracted from the umbilical cords of healthy donors who have passed safety screening.
The collected umbilical cord is processed in a sterile environment, blood vessels are removed to efficiently extract stem cells, leaving only the umbilical cord tissue.

Next, stem cells are carefully extracted without damaging cell quality, and cultured under strict management standards.
This allows us to provide stem cells with proven safety and effectiveness.

There are various types of stem cells, and we will explain in detail how stem cells derived from Wharton's Jelly are specifically superior to those derived from fat or bone marrow.

Effectiveness of Wharton's Jelly Stem Cells

Wharton's Jelly Stem Cells are mesenchymal stem cells extracted from the umbilical cord, and have garnered significant attention in the field of regenerative therapy due to their remarkable capabilities.
Specifically, the following characteristics lead them to be called "miracle stem cells," from which high therapeutic effectiveness can be expected.

High Proliferative Capacity

Wharton's Jelly Stem Cells have a very high proliferation rate.
This means the ability to significantly increase the number of cells in a short time.

Therefore, the required cells can be cultivated and prepared quickly, and can be used immediately in the field of regenerative therapy.
Reports have shown that the proliferation rate is faster compared to stem cells derived from adult tissues, such as bone marrow-derived stem cells.

Differentiation Capability

Wharton's Jelly Stem Cells possess superior differentiation capabilities, allowing them to differentiate into various cell types including bone, cartilage, adipose tissue, muscle, and neural cells.

With this flexible differentiation capability, it is possible to repair multiple tissues from a single type of stem cell, and it is expected to meet various medical needs, such as regenerative therapy for damaged organs and tissues.

Anti-inflammatory Effect

Wharton's Jelly Stem Cells have prominent anti-inflammatory effects (inflammation-suppressing action).
This modulates the overactive response caused by the immune system, suppresses the production of inflammatory cytokines (inflammatory substances released by immune cells), and reduces swelling and tissue damage.

This enables the alleviation of chronic inflammation in disease and the improvement of an environment conducive to tissue repair.

Immunomodulatory Effect

Wharton's Jelly Stem Cells have the power to precisely control immune function.
Therefore, the transplanted cells are not easily attacked by the body's immune system, and the risk of rejection can be suppressed.

Typically, cells from another individual are recognized by the immune system as foreign. However, Wharton's Jelly Stem Cells possess characteristics that make them less susceptible to immune attack.

It also secretes substances that suppress excessive immune responses, and possesses actions to mitigate bodily inflammation and promote homeostasis.

This method enables their use in treatment even with imperfect HLA (immune compatibility) matching, providing the benefit of applicability to a broader patient population.

Furthermore, effects on autoimmune diseases resulting from stochastic immune events are also anticipated, and research is currently underway.

Paracrine Effect

The paracrine effect refers to the phenomenon in which cells secrete bioactive substances, such as cytokines and growth factors, into their local environment, subsequently acting on adjacent cells to elicit a variety of effects.

Wharton's Jelly Stem Cells secrete a diverse array of beneficial factors into their surrounding microenvironment, which stimulate adjacent cells to promote tissue repair and mitigate inflammation.

Although stem cells themselves do not directly differentiate into damaged tissue, they are capable of stimulating the functions of adjacent cells via secreted factors, thereby ultimately facilitating the repair of the damaged tissue.

For example, it has been reported that secretory factors contained within Wharton's Jelly Stem Cell conditioned medium (the fluid obtained from cultured cells) promote the proliferation of dermal fibroblasts (cells responsible for wound healing) and enhance the expression of genes involved in wound healing.

In this manner, Wharton's Jelly Stem Cells, via paracrine effects, indirectly promote tissue repair by influencing surrounding cells and exert therapeutic effects.

The Most Ethically Safe Stem Cell Source

Among the stem cells employed in regenerative therapy, some are subject to ethical debate concerning their extraction methods.

However, Wharton's Jelly Stem Cells are extracted from the umbilical cord, a naturally discarded byproduct of birth. This eliminates ethical concerns, and a major benefit is the demonstrated near-zero risk, substantiated by extensive long-term clinical data and safety trials.

The umbilical cord from which Wharton's Jelly cells are extracted is collected at birth during a C-section.
In countries other than Indonesia, the percentage of births via C-section is high, so there are many opportunities to extract healthy stem cells.

Demonstrates effectiveness even for congenital and intractable diseases.

Wharton's Jelly Stem Cells, extracted from the umbilical cords of healthy newborns, demonstrate effectiveness even in congenital and intractable diseases that the body's own mechanisms cannot cure.

In previous clinical results, blind patients could see, and high effectiveness was also recognized in the improvement of autism.
Wharton's Jelly Stem Cells also promote nerve cell regeneration, which was previously believed to be unable to regenerate.

Therefore, efficacy is also anticipated for Parkinson's disease, spinocerebellar atrophy, and Alzheimer's disease, for which no effective treatment methods are currently available.

Rigorous and Unique Cell Selection Standards 23C

23C not only uses Wharton's Jelly Stem Cells, but also selects cells with higher activity.
To maximize cell purity and differentiation ability, only cells up to the 4th generation (P4) were used, and senescent and low-functioning cells were removed.

Wharton's Jelly mesenchymal stem cells (WJ-MSCs) are a type of stem cell that are readily harvested, possess high differentiation potential, are immunoprivileged, and do not present legal or ethical concerns. WJ-MSCs demonstrate several characteristics of embryonic stem cells from both phenotypic and genetic perspectives.

WJ-MSCs possess immunomodulatory properties involved in both innate and adaptive immunity. Numerous studies have demonstrated that when WJ-MSCs are administered to critically ill patients unresponsive to standard treatments, beneficial effects are observed even when human leukocyte antigen (HLA) types are not perfectly matched.

Sumber: Int J Stem Cells. 2019; 12(2): 218–226. Diterbitkan online 2019 Apr 30.
PubMed Central Identifier: PMC6657936

The Therapeutic Power of Wharton's Jelly Stem Cells Provided by 23C

23C provides Wharton's Jelly Stem Cell therapy that meets stringent standards for safety, quality, and efficacy.

Least Differentiated Stem Cells Derived from Healthy Donors

The stem cells used by 23Century are mesenchymal stem cells (WJ-MSC) extracted from the Wharton's Jelly of a newborn baby's umbilical cord.
It is not affected by aging, excels in proliferation, differentiation, and immune adjustment functions, resulting in high therapeutic effectiveness and a low risk of side effects.
Donors are chosen only from healthy mothers who pass strict infection screening and genetic risk screening, and we use safe cells without ethical issues.

State-of-the-Art Cultivation Facilities Certified by Malaysia's National Pharmaceutical Regulatory Agency (NPRA)

23Century stem cells are produced in a cGMP-certified cell culture facility that has received approval from the National Pharmaceutical Regulatory Agency (NPRA) of the Ministry of Health Malaysia.
This facility performs cell culture in an acid-free environment (cleanroom), quality management, virus testing, genetic testing, etc., and provides safe and high-quality stem cells that meet international standards.

Furthermore, by consistently managing operations from culture to administration, we can provide high-quality cells at a competitive price without intermediaries.

Optimization and Individualized Treatment Plan

For each patient's symptoms and goals, the specialist explains the relevant disease and its expected effects in detail, and formulates an optimal treatment plan.
The optimal route for stem cell administration is also chosen for each disease, such as infusion, intra-articular injection, and intravenous injection, and is customized to achieve maximum therapeutic effectiveness.

Rigorous Quality Testing and Traceability Management

We exclusively provide stem cells that have undergone rigorous quality testing during the cell culture process.

• Bacterial and viral filtration (ensuring zero risk of infection)
• A survival rate (activity rate) of at least 80% for the utilized cells, significantly exceeding the government standard of 70% or more.
• Genetic mutation screening (confirming zero cancer risk)

Furthermore, strict cell lot management and administration records, and a traceability system are established to track which cells were given to which patient.
Hereby, the safety and transparency of therapy are guaranteed.

Full Support by Indonesian Staff

Overseas medical treatment often comes with concerns. However, 23Century employs Indonesian staff to provide support, starting with pre-travel consultations, thereby ensuring that even first-time patients can receive care with peace of mind.

Benefits of Receiving Wharton's Jelly Stem Cell Therapy

Wharton's Jelly Stem Cells have a higher regenerative capacity compared to other stem cells (bone marrow-derived, fat-derived), and there is almost no risk of rejection.
Therefore, it is suitable for the following diseases and purposes.

※The foregoing information serves only as an illustration of expected or reported effects and does not guarantee identical outcomes for all individuals. Due to individual variations in effects based on patient condition and disease, a detailed explanation will be provided during the consultation.